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Cell-laden Microengineered and Mechanically Tunable Hybrid Hydrogels of Gelatin and Graphene Oxide
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology.
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2013 (English)In: Advanced Materials, ISSN 0935-9648, E-ISSN 1521-4095, Vol. 25, no 44, 6385-6391 p.Article in journal (Refereed) Published
Abstract [en]

Incorporating graphene oxide inside GelMA hydrogels enhances their mechanical properties and reduces UV-induced cell damage while preserving their favorable characteristics for 3D cell encapsulation. NIH-3T3 fibroblasts encapsulated in GO-GelMA microgels demonstrate excellent cellular viability, proliferation, spreading, and alignment. GO reinforcement combined with a multi-stacking approach offers a facile engineering strategy for the construction of complex artificial tissues.

Place, publisher, year, edition, pages
2013. Vol. 25, no 44, 6385-6391 p.
Keyword [en]
graphene, microgels, tunable stiffness, tissue engineering, multilayer constructs
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:uu:diva-213932DOI: 10.1002/adma.201301082ISI: 000327692500006OAI: oai:DiVA.org:uu-213932DiVA: diva2:683631
Available from: 2014-01-05 Created: 2014-01-05 Last updated: 2017-12-06Bibliographically approved

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