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Quality of life in patients with endometriosis and the effect of pertubation with lidocaine - a randomized controlled trial
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2013 (English)In: Acta Obstetricia et Gynecologica Scandinavica, ISSN 0001-6349, E-ISSN 1600-0412, Vol. 92, no 12, 1375-1382 p.Article in journal (Refereed) Published
Abstract [en]

ObjectivePertubation with lidocaine has been shown to reduce pain (on a VAS-scale) in women with endometriosis. A clinical study was performed to evaluate the effect of lidocaine pertubations on quality of life. DesignDouble-blind, randomized and controlled trial. SettingThree outpatient units in Stockholm, Sweden. PopulationEligible patients had endometriosis with dysmenorrhoic pain >VAS 50mm. MethodsThe patients were randomized to pre-ovulatory pertubations with lidocaine (n=24) or placebo (n=18) during three consecutive menstrual cycles. The procedure comprised passing the solution through the uterus and the Fallopian tubes via an intracervical balloon catheter. The effect was evaluated with the validated Endometriosis Health Profile-30 questionnaire before and after treatments. Main outcome measuresChanges in scores at six and 12 months from baseline were compared between the groups with the Mann-Whitney U-test. ResultsAfter 6months there was a significant difference between the lidocaine (n=19) and the placebo (n=16) groups for the dimension social support (median -18.8 vs. -6.3, p=0.034), whereas there were no significant differences for the other dimensions after 6 or 12months. The mean changes in the lidocaine group were above the minimal important difference levels in eight of 12 measurements of quality of life dimensions compared with two of 12 in the placebo group. ConclusionsThis clinical trial indicates that pertubations with lidocaine might improve the social support dimension of quality of life in patients with endometriosis.

Place, publisher, year, edition, pages
2013. Vol. 92, no 12, 1375-1382 p.
Keyword [en]
Endometriosis, health profile, lidocaine, pertubation, quality of life
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-213902DOI: 10.1111/aogs.12257ISI: 000327422800007OAI: oai:DiVA.org:uu-213902DiVA: diva2:683738
Available from: 2014-01-06 Created: 2014-01-05 Last updated: 2014-01-06Bibliographically approved

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Edelstam, Greta
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Obstetrics and Gynaecology
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