uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Evolution of sex differences in lifespan and aging: Causes and constraints
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Animal ecology. (Ageing Research Group)
2013 (English)In: Bioessays, ISSN 0265-9247, E-ISSN 1521-1878, Vol. 35, no 8, 717-724 p.Article in journal (Refereed) Published
Abstract [en]

Why do the two sexes have different lifespans and rates of aging? Two hypotheses based on asymmetric inheritance of sex chromosomes (unguarded X) or mitochondrial genomes (mother's curse) explain sex differences in lifespan as sex-specific maladaptation leading to increased mortality in the shorter-lived sex. While asymmetric inheritance hypotheses equate long life with high fitness, considerable empirical evidence suggests that sexes resolve the fundamental tradeoff between reproduction and survival differently resulting in sex-specific optima for lifespan. However, selection for sex-specific values in life-history traits is constrained by intersexual genetic correlations resulting in intra-locus sexual conflict over optimal lifespan. The available data suggest that the evolution of sexual dimorphism only partially resolves these conflicts. Sexual conflict over optimal trait values, which has been demonstrated in model organisms and in humans, is likely to play a key role in shaping the evolution of lifespan, as well as in maintaining genetic variation for sex-specific diseases.

Place, publisher, year, edition, pages
2013. Vol. 35, no 8, 717-724 p.
Keyword [en]
aging, disease, mitochondria, senescence, sex chromosomes, sexual conflict, sexual selection
National Category
Natural Sciences
URN: urn:nbn:se:uu:diva-214009DOI: 10.1002/bies.201300021ISI: 000327774300010OAI: oai:DiVA.org:uu-214009DiVA: diva2:683793
Available from: 2014-01-06 Created: 2014-01-06 Last updated: 2014-01-06Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Maklakov, Alexei A.
By organisation
Animal ecology
In the same journal
Natural Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 193 hits
ReferencesLink to record
Permanent link

Direct link