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Microglia and Neuropathic Pain
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuroanatomy.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuroanatomy.
2013 (English)In: CNS & Neurological Disorders: Drug Targets, ISSN 1871-5273, E-ISSN 1996-3181, Vol. 12, no 6, 768-772 p.Article in journal (Refereed) Published
Abstract [en]

Neuropathic pain is a serious consequence of injury or disease in the nervous system itself. Current treatment options for this condition are often unsatisfactory. From being originally viewed as a diseased caused by neuronal dysfunction, a growing body of evidence implicate activated microglia as a key player in the development of this pain condition. In this review, some of the evidence for this proposal is briefly discussed and placed in a translational context, pointing out the difficulties in translating commonly used animal models of neuropathic pain to the clinical condition, as well as emphasizing the broader role of activated microglia in the injured or diseased nervous system.

Place, publisher, year, edition, pages
2013. Vol. 12, no 6, 768-772 p.
Keyword [en]
Nerve injury, spinal cord injury, neuropathy, cytokine, chemokine, purine receptor, plasticity
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-214056DOI: 10.1002/glia.20871ISI: 000327797200009PubMedID: 24047529OAI: oai:DiVA.org:uu-214056DiVA: diva2:683941
Available from: 2014-01-07 Created: 2014-01-07 Last updated: 2017-12-06Bibliographically approved

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Aldskogius, HåkanKozlova, Elena N.

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