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Evidence for multiple forms and modifications of human POT1
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Cancer and Vascular Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research. Uppsala University, Science for Life Laboratory, SciLifeLab.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Cancer and Vascular Biology.
2013 (English)In: DNA Repair, ISSN 1568-7864, E-ISSN 1568-7856, Vol. 12, no 11, 876-877 p.Article in journal, Letter (Refereed) Published
Abstract [en]

Human POT1, a widely studied telomere protector protein is perceived to be expressed as a single 70 kDa form. A survey of the literature as well as different commercially available antibodies against POT1 suggests occurrence of multiple forms of POT1. Knowledge about possible various forms of an important protein like POT1 is necessary for our understanding about its function. We have discovered that POT1 exists in at least three consistently occurring forms; 90,70 and 45 kDa. The unexpected molecular weights of POT1 seem to be associated with SUMO1 and ubiquitin conjugation; the latter occurring at a double lysine residue at 289-KK-290. We also present evidence that the relative abundance of the different POT1 forms can be altered by experimental modulation of POT1 nuclear localization. We thus present strong evidence that there are post-translational modifications of POT1 that can affect its molecular weight as well as intracellular localization and function.

Place, publisher, year, edition, pages
2013. Vol. 12, no 11, 876-877 p.
Keyword [en]
POT1, Post-translational modifications, Unexpected molecular weights
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-214320DOI: 10.1016/j.dnarep.2013.08.014ISI: 000327579200003OAI: oai:DiVA.org:uu-214320DiVA: diva2:684686
Available from: 2014-01-08 Created: 2014-01-08 Last updated: 2017-12-06Bibliographically approved

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Singh, UmashankarMaturi, VarunWestermark, Bengt

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