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Level of lactate in amniotic fluid and its relation to the use of oxytocin and adverse neonatal outcome
Department of Clinical Science and Education, Section of Obstetrics and Gynecology, Karolinska Institute, Söder Hospital, Stockholm, Sweden.
Department of Obstetrics and Gynecology, School of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Department of Molecular and Cellular Physiology, Institute of Translational Medicine, University of Liverpool, UK.
Department of Clinical Science, Obstetrics and Gynecology, University Hospital of Umeå, Sweden.
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2014 (English)In: Acta Obstetricia et Gynecologica Scandinavica, ISSN 0001-6349, E-ISSN 1600-0412, Vol. 93, no 1, 80-85 p.Article in journal (Refereed) Published
Abstract [en]

Objective: To assess whether the frequency of adverse neonatal outcome at delivery is related to thelevel of lactate in amniotic fluid and to the use of oxytocin. 

Design: Prospective observational study. 

Setting: Soder Hospital, Stockholm, Sweden. 

Population: Seventy-four women in active labor with a gestational age 36weeks and mixed parity. 

Methods: Levels of lactate in amniotic fluid were analyzed bedside from an intrauterine catheter every 30min during labor. Deliveries were divided into groups with and without oxytocin. 

Main outcome measures: The frequency of adverse neonatal outcome at delivery. 

Result: Of the deliveries 13.5% (10/74) concluded with an adverse neonatal outcome. The levels oflactate in amniotic fluid increased during labor, more so in deliveries where oxytocin was used. In thegroup with an adverse neonatal outcome, the level of lactate in amniotic fluid was significantly higher inthe final sample before delivery (p=0.04). In 18 deliveries, stimulation with oxytocin was temporarily halted for at least 30min due to overly stimulated labor contractions. A decreasing level of lactate inamniotic fluid was shown within a median 5%/30min. In the group where the administration of oxytocinwas halted, there was no adverse neonatal outcome. 

Conclusion: The frequency of adverse neonatal outcome was associated with the level of lactate inamniotic fluid and with the use of oxytocin. The level of lactate in amniotic fluid may be an additional valuable tool when oxytocin is administered during labor.

Place, publisher, year, edition, pages
2014. Vol. 93, no 1, 80-85 p.
National Category
Obstetrics, Gynecology and Reproductive Medicine
URN: urn:nbn:se:uu:diva-214519DOI: 10.1111/aogs.12261ISI: 000328435300012OAI: oai:DiVA.org:uu-214519DiVA: diva2:684991
Available from: 2014-01-08 Created: 2014-01-08 Last updated: 2014-12-18Bibliographically approved

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Darj, ElisabethÅkerud, Helena
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