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Tillverkning av mikronålar för medicinsk tillämpning
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
2014 (Swedish)Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesisAlternative title
Manufacturing of microneedles for medical applications (English)
Abstract [en]

Transdermal drug delivery, besides painful

injections with syringes, has long been associated

with small size particle pharmaceuticals, which can

diffuse through the skin. This method of drug

administration has only been applicable on a small

number of drugs, where active molecules are small

and delivery time should or can be long.

Other drug delivery options are oral administration

and injection with hypodermic needles (ordinary

hospital syringes). In oral administration the

stomach and liver tend to dissolve the drug and the

effect becomes more difficult to anticipate, and

drug delivery rates difficult to control. Hypodermic

needles are used as a mean of drug injection

directly into the bloodstream. This method is

painful and risks infection due to tissue damage

and skin penetration.

One way to get a painless non-damaging technique

with high delivery rate that still can delivery large

molecules is to manufacture an array of microscopic

hollow needles and equip them with a pumping unit

that delivers the correct amount of drugs.

This thesis shows the technique and possibility of

manufacture micromachined needles using low cost

techniques of Ion Track Technology (radiation of

heavy ions creates porous materials), electroless

deposition (non-current activated wet chemistry

method of depositing metal) and electroplating. It

also shows that it is possible to combine the

needles with a thermal activated pump (actuator)

unit made of paraffin to transport liquid through

the needles. Hence the experiments show that

microneedles and actuator fulfil the fundamentals

towards micro scaled drug administration,

transportation of fluid.

Place, publisher, year, edition, pages
2014. , 47 p.
UPTEC Q, ISSN 1401-5773 ; 14001
National Category
Engineering and Technology
URN: urn:nbn:se:uu:diva-215112OAI: oai:DiVA.org:uu-215112DiVA: diva2:686118
Educational program
Master Programme in Materials Engineering
Available from: 2014-01-10 Created: 2014-01-10 Last updated: 2014-01-10Bibliographically approved

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