Independent thesis Advanced level (professional degree), 20 credits / 30 HE credits
Transdermal drug delivery, besides painful
injections with syringes, has long been associated
with small size particle pharmaceuticals, which can
diffuse through the skin. This method of drug
administration has only been applicable on a small
number of drugs, where active molecules are small
and delivery time should or can be long.
Other drug delivery options are oral administration
and injection with hypodermic needles (ordinary
hospital syringes). In oral administration the
stomach and liver tend to dissolve the drug and the
effect becomes more difficult to anticipate, and
drug delivery rates difficult to control. Hypodermic
needles are used as a mean of drug injection
directly into the bloodstream. This method is
painful and risks infection due to tissue damage
and skin penetration.
One way to get a painless non-damaging technique
with high delivery rate that still can delivery large
molecules is to manufacture an array of microscopic
hollow needles and equip them with a pumping unit
that delivers the correct amount of drugs.
This thesis shows the technique and possibility of
manufacture micromachined needles using low cost
techniques of Ion Track Technology (radiation of
heavy ions creates porous materials), electroless
deposition (non-current activated wet chemistry
method of depositing metal) and electroplating. It
also shows that it is possible to combine the
needles with a thermal activated pump (actuator)
unit made of paraffin to transport liquid through
the needles. Hence the experiments show that
microneedles and actuator fulfil the fundamentals
towards micro scaled drug administration,
transportation of fluid.
2014. , 47 p.