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Targeting the PDGF signaling pathway in tumor treatment
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research. Uppsala University, Science for Life Laboratory, SciLifeLab.
2013 (English)In: Cell Communication and Signaling, ISSN 1478-811X, Vol. 11, 97- p.Article, review/survey (Refereed) Published
Abstract [en]

Platelet-derived growth factor (PDGF) isoforms and PDGF receptors have important functions in the regulation of growth and survival of certain cell types during embryonal development and e.g. tissue repair in the adult. Overactivity of PDGF receptor signaling, by overexpression or mutational events, may drive tumor cell growth. In addition, pericytes of the vasculature and fibroblasts and myofibroblasts of the stroma of solid tumors express PDGF receptors, and PDGF stimulation of such cells promotes tumorigenesis. Inhibition of PDGF receptor signaling has proven to useful for the treatment of patients with certain rare tumors. Whether treatment with PDGF/PDGF receptor antagonists will be beneficial for more common malignancies is the subject for ongoing studies.

Place, publisher, year, edition, pages
2013. Vol. 11, 97- p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-215587DOI: 10.1186/1478-811X-11-97ISI: 000329172500001PubMedID: 24359404OAI: oai:DiVA.org:uu-215587DiVA: diva2:687681
Available from: 2014-01-15 Created: 2014-01-15 Last updated: 2014-01-27Bibliographically approved

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Heldin, Carl-Henrik
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