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MRI evidence of endolymphatic impermeability to the gadolinium molecule in the in vivo mouse inner ear at 9.4 tesla
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2013 (English)In: The Open Neuroimaging Journal, ISSN 1874-4400, Vol. 7, 27-31 p.Article in journal (Refereed) Published
Abstract [en]


Previous in vivo experimental magnetic resonance imaging (MRI) investigations of the mammalian inner ear at 4.7 Tesla have indicated that intravenously injected gadolinium (Gd) penetrates the perilymphatic labyrinth, but not the endolymphatic membranous labyrinth. In the present study, high field MRI at 9.4T was used to visualize the in vivo mouse vestibulo-cochlea system, and to determine whether the endolymphatic system is permeable to a Gd complex.


A 9.4 T Varian magnet equipped with a 12 cm inner diameter gradient system with maximum gradient strength of 600 mT/m, a millipede coil (Varian design) and a Gd contrast agent were used for image acquisition in the normal C57 BL-6 mouse.


High-resolution 2D and 3D images of the mouse cochlea were acquired within 80 minutes following intravenous injection of Gd. Gd initially permeated the perilymphatic scala tympani and scala vestibuli, and permitted visualization of both cochlear turns from base to apex. The superior, inferior and lateral semicircular canals were subsequently visualized in 3 planes. The membranous endolymphatic labyrinth was impermeable to intravenously injected Gd, and thus showed no apparent uptake of Gd at 9.4T.


The 9.4T field strength MRI permitted acquisition of high resolution images of anatomical and physiological features of the normal, wild type mouse perilymphatic inner ear in vivo, and provided further evidence that the endolymphatic system is impermeable to intravenously injected Gd.

Place, publisher, year, edition, pages
2013. Vol. 7, 27-31 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-216225DOI: 10.2174/1874440001307010027PubMedID: 23894262OAI: oai:DiVA.org:uu-216225DiVA: diva2:689278
Available from: 2014-01-20 Created: 2014-01-20 Last updated: 2014-01-30Bibliographically approved

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Laurell, Göran
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Otolaryngology and Head and Neck Surgery
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