uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Expression of CXCL10 is associated with response to radiotherapy and overall survival in squamous cell carcinoma of the tongue
Show others and affiliations
2014 (English)In: Tumor Biology, ISSN 1010-4283, E-ISSN 1423-0380, Vol. 35, no 5, 4194-4198 p.Article in journal (Refereed) Published
Abstract [en]

Five-year survival for patients with oral cancer has been disappointingly stable during the last decades, creating a demand for new biomarkers and treatment targets. Lately, much focus has been set on immunomodulation as a possible treatment or an adjuvant increasing sensitivity to conventional treatments. The objective of this study was to evaluate the prognostic importance of response to radiotherapy in tongue carcinoma patients as well as the expression of the CXC-chemokines in correlation to radiation response in the same group of tumours. Thirty-eight patients with tongue carcinoma that had received radiotherapy followed by surgery were included. The prognostic impact of pathological response to radiotherapy, N-status, T-stage, age and gender was evaluated using Cox's regression models, Kaplan-Meier survival curves and chi-square test. The expression of 23 CXC-chemokine ligands and their receptors were evaluated in all patients using microarray and qPCR and correlated with response to treatment using logistic regression. Pathological response to radiotherapy was independently associated to overall survival with a 2-year survival probability of 81 % for patients showing a complete pathological response, while patients with a non-complete response only had a probability of 42 % to survive for 2 years (p = 0.016). The expression of one CXC-chemokine, CXCL10, was significantly associated with response to radiotherapy and the group of patients with the highest CXCL10 expression responded, especially poorly (p = 0.01). CXCL10 is a potential marker for response to radiotherapy and overall survival in patients with squamous cell carcinoma of the tongue.

Place, publisher, year, edition, pages
2014. Vol. 35, no 5, 4194-4198 p.
National Category
Cancer and Oncology
URN: urn:nbn:se:uu:diva-216228DOI: 10.1007/s13277-013-1549-6ISI: 000335759800029PubMedID: 24395654OAI: oai:DiVA.org:uu-216228DiVA: diva2:689283
Swedish Cancer Society, 13 0716
Available from: 2014-01-20 Created: 2014-01-20 Last updated: 2014-06-25Bibliographically approved

Open Access in DiVA

fulltext(347 kB)115 downloads
File information
File name FULLTEXT01.pdfFile size 347 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Laurell, Göran
By organisation
Otolaryngology and Head and Neck Surgery
In the same journal
Tumor Biology
Cancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar
Total: 115 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 288 hits
ReferencesLink to record
Permanent link

Direct link