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Mass Spectrometry Imaging, an Emerging Technology in Neuropsychopharmacology
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
2014 (English)In: Neuropsychopharmacology, ISSN 0893-133X, E-ISSN 1740-634X, Vol. 39, no 1, 34-49 p.Article, review/survey (Refereed) Published
Abstract [en]

Mass spectrometry imaging is a powerful tool for directly determining the distribution of proteins, peptides, lipids, neurotransmitters, metabolites and drugs in neural tissue sections in situ. Molecule-specific imaging can be achieved using various ionization techniques that are suited to different applications but which all yield data with high mass accuracies and spatial resolutions. The ability to simultaneously obtain images showing the distributions of chemical species ranging from metal ions to macromolecules makes it possible to explore the chemical organization of a sample and to correlate the results obtained with specific anatomical features. The imaging of biomolecules has provided new insights into multiple neurological diseases, including Parkinson's and Alzheimer's disease. Mass spectrometry imaging can also be used in conjunction with other imaging techniques in order to identify correlations between changes in the distribution of important chemical species and other changes in the properties of the tissue. Here we review the applications of mass spectrometry imaging in neuroscience research and discuss its potential. The results presented demonstrate that mass spectrometry imaging is a useful experimental method with diverse applications in neuroscience.

Place, publisher, year, edition, pages
2014. Vol. 39, no 1, 34-49 p.
Keyword [en]
mass spectrometry imaging, protein, neuropeptide, neurotransmitter, lipid
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-216246DOI: 10.1038/npp.2013.215ISI: 000328584500004OAI: oai:DiVA.org:uu-216246DiVA: diva2:689354
Available from: 2014-01-20 Created: 2014-01-20 Last updated: 2017-12-06Bibliographically approved

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Shariatgorji, MohammadrezaAndrén, Per E.

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