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Time trends in T3 to T4 laryngeal cancer: a population-based long-term analysis
Regional Cancer Centre, Uppsala, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Oncology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery.
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2014 (English)In: Head and Neck, ISSN 1043-3074, E-ISSN 1097-0347, Vol. 36, no 12, 1727-1731 p.Article in journal (Refereed) Published
Abstract [en]


A decline in laryngectomies and survival in laryngeal cancer has been reported, especially among advanced tumors.


Out of 1058 patients with laryngeal cancer diagnosed 1978-2007 in the Uppsala-Örebro-region in Sweden 263 T3-4 tumors treated with curative intent were studied retrospectively. Two time periods were defined, 1978-1992 and 1993-2007.


Glottic tumors decreased constituting 68.6% of cases 1978-1992 and 47.9% 1993-2007. Laryngectomy was performed in 38.8% and in 34.5% in the corresponding time periods. The use of laryngectomy was not strongly prognostic. A decline in overall survival over time could only be identified for the first year of follow-up. Chemotherapy was only used in a minority of cases.


The marked decrease of glottic site may mark a shift in etiology. Laryngectomy was not strongly associated with improved survival. The absence of improved survival calls for intensified research.

Place, publisher, year, edition, pages
2014. Vol. 36, no 12, 1727-1731 p.
National Category
Cancer and Oncology
URN: urn:nbn:se:uu:diva-216387DOI: 10.1002/hed.23524ISI: 000344801200013PubMedID: 24166872OAI: oai:DiVA.org:uu-216387DiVA: diva2:689630
Available from: 2014-01-21 Created: 2014-01-21 Last updated: 2014-12-18Bibliographically approved

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Holmberg, LarsBergqvist, MichaelLinder, ArneEkman, SimonBlomquist, Erik
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