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A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia
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2014 (English)In: Nature Genetics, ISSN 1061-4036, Vol. 46, no 1, 56-+ p.Article in journal (Refereed) Published
Abstract [en]

Genome-wide association studies (GWAS) of chronic lymphocytic leukemia (CLL) have shown that common genetic variation contributes to the heritable risk of CLL. To identify additional CLL susceptibility loci, we conducted a GWAS and performed a meta-analysis with a published GWAS totaling 1,739 individuals with CLL (cases) and 5,199 controls with validation in an additional 1,144 cases and 3,151 controls. A combined analysis identified new susceptibility loci mapping to 3q26.2 (rs10936599, P = 1.74 x 10(-9)), 4q26 (rs6858698, P = 3.07 x 10(-9)), 6q25.2 (IPCEF1, rs2236256, P = 1.50 x 10(-10)) and 7q31.33 (POT1, rs17246404, P = 3.40 x 10(-8)). Additionally, we identified a promising association at 5p15.33 (CLPTM1L, rs31490, P = 1.72 x 10(-7)) and validated recently reported putative associations at 5p15.33 (TERT, rs10069690, P = 1.12 x 10(-10)) and 8q22.3 (rs2511714, P = 2.90 x 10(-9)). These findings provide further insights into the genetic and biological basis of inherited genetic susceptibility to CLL.

Place, publisher, year, edition, pages
2014. Vol. 46, no 1, 56-+ p.
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Medical and Health Sciences
URN: urn:nbn:se:uu:diva-216735DOI: 10.1038/ng.2843ISI: 000329113500013OAI: oai:DiVA.org:uu-216735DiVA: diva2:691177
Available from: 2014-01-27 Created: 2014-01-24 Last updated: 2014-01-27Bibliographically approved

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Mansouri, LarryRosenquist, Richard
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