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Chemotherapeutic drug sensitivity of primary cultures of epithelial ovarian cancer cells from patients in relation to tumour characteristics and therapeutic outcome
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Oncology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Oncology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Endocrine Surgery.
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2014 (English)In: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 53, no 2, 242-250 p.Article in journal (Refereed) Published
Abstract [en]

Background

A number of chemotherapeutic drugs are active in epithelial ovarian cancer (EOC) but so far choice of drugs for treatment is mostly empirically based. Testing of drug activity in tumour cells from patients might provide a rationale for a more individualised approach for drug selection.

Material and methods

Sensitivity of EOC to chemotherapeutic drugs was analysed in 125 tumour samples from 112 patients using a short-term primary culture assay based on the concept of total cell kill. Sensitivity was related to tumour histology, treatment status and clinical tumour response.

Results

For most EOC standard drugs serous high grade and clear cell EOC were the most sensitive subtypes and the mucinous tumours the most resistant subtype. Docetaxel, however, tended to show the opposite pattern. Samples from previously treated patients tended to be more resistant than those from treatment naive patients. The activity of cisplatin correlated with that of other drugs with the exception of docetaxel. Tumour samples from two sites in the same patient at the same occasion showed similar cisplatin sensitivity in contrast to samples taken at different occasions. Samples from patients responding in the clinic to treatment were more sensitive to most drugs than samples from non-responding patients. At the individual patient level, drug sensitivity in vitro compared with clinical response showed sensitivities and specificities in the 83-100% and 55-83% ranges, respectively.

Conclusions

Assessment of EOC tumour cell drug sensitivity in vitro provides clinically relevant and potentially useful information for the optimisation of drug treatment.

Place, publisher, year, edition, pages
2014. Vol. 53, no 2, 242-250 p.
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-217645DOI: 10.3109/0284186X.2013.794956ISI: 000329522000011OAI: oai:DiVA.org:uu-217645DiVA: diva2:695870
Available from: 2014-02-12 Created: 2014-02-04 Last updated: 2017-12-06Bibliographically approved

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von Heideman, AnneTholander, BengtGrundmark, BirgittaMahteme, HaileLarsson, RolfNygren, Peter

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OncologyEndocrine SurgeryDepartment of Women's and Children's HealthColorectal SurgeryDepartment of Radiology, Oncology and Radiation ScienceCancer Pharmacology and Computational Medicine
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