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Immobilization of Sertoli cells on islets of Langerhans
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
2013 (English)In: BIOMATER SCI-UK, ISSN 2047-4830, Vol. 1, no 3, 315-321 p.Article in journal (Refereed) Published
Abstract [en]

Sertoli cells play a crucial role in creating the immunoprivileged environment of the testis. We examined the survival of islets of Langerhans after co-transplantation with Sertoli cells. Sertoli cells near islets should protect the graft from rejection. In this study, conjugates of single stranded oligonucleotides, poly(ethylene glycol) and phospholipids (ssDNA-PEG-DPPE) were used to immobilize Sertoli cells on islets. The 20-mer of deoxyadenylic acid (oligo(dA)(20)) and 20-mer of deoxythymidylic acid (oligo(dT)(20)) were presented as ssDNAs on the surfaces of Sertoli cells and islets, respectively, through the hydrophobic interaction between a lipid unit of the conjugates and the cell membrane. The Sertoli cells were immobilized on the islets through hybridization between oligo(dA)(20) and oligo(dT)(20). When Sertoli cell-immobilized islets were infused into the liver of mice through the portal vein, the Sertoli cells remained around the islets.

Place, publisher, year, edition, pages
2013. Vol. 1, no 3, 315-321 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-219228DOI: 10.1039/c2bm00048bISI: 000330133600009OAI: oai:DiVA.org:uu-219228DiVA: diva2:698655
Available from: 2014-02-24 Created: 2014-02-24 Last updated: 2014-02-24Bibliographically approved

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Teramura, Yuji

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