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Parameterisation affects identifiability of population models
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
2014 (English)In: Journal of Pharmacokinetics and Pharmacodynamics, ISSN 1567-567X, E-ISSN 1573-8744, Vol. 41, no 1, 81-86 p.Article in journal (Refereed) Published
Abstract [en]

Identifiability is an important aspect of model development. In this work, using a simple one compartment population pharmacokinetic model, we show that identifiability of the variances of the random effects parameters are affected by the parameterisation of the fixed effects parameters.

Place, publisher, year, edition, pages
2014. Vol. 41, no 1, 81-86 p.
Keyword [en]
Identifiability, Bateman model, Parameterisation, Population models
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-219192DOI: 10.1007/s10928-013-9347-8ISI: 000330126400007OAI: oai:DiVA.org:uu-219192DiVA: diva2:698996
Available from: 2014-02-25 Created: 2014-02-24 Last updated: 2014-02-25Bibliographically approved

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Korell, Julia
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