uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Neurogenesis in the Striatum of the Adult Human Brain
Karolinska Institut.
Karolinska Institut.
University of Lyon, Villeurbanne, France.
Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy. (Jonfysik)ORCID iD: 0000-0003-2787-8801
Show others and affiliations
2014 (English)In: Cell, ISSN 0092-8674, E-ISSN 1097-4172, Vol. 156, no 5, 1072-1083 p.Article in journal (Refereed) Published
Abstract [en]

Neurons are added throughout life in the hippocampus and olfactory bulb in most mammals, although humans represent an exception without detectable olfactory bulb neurogenesis. Nevertheless, neuroblasts are generated in the lateral ventricle wall in humans, the neurogenic niche for olfactory bulb neurons in other mammals. We show that, in humans, new neurons integrate adjacent to this neurogenic niche, in the striatum. The neuronal turnover in the striatum appears restricted to interneurons and we show that postnatally generated striatal neurons are preferentially depleted in Huntington’s disease. This demonstrates a unique pattern of neurogenesis in the adult human brain.  

Place, publisher, year, edition, pages
Cambridge, MA 02139, USA: Elsevier, 2014. Vol. 156, no 5, 1072-1083 p.
Keyword [en]
Neurogenesis, Striatum, brain, cell renewal, bomb-peak
National Category
Accelerator Physics and Instrumentation Biophysics
Research subject
Physics with specialization in Biophysics
URN: urn:nbn:se:uu:diva-219356DOI: 10.1016/j.cell.2014.01.044ISI: 000332083900022OAI: oai:DiVA.org:uu-219356DiVA: diva2:699427
Linnéprojekt. The Human Regenerative Map
Swedish Research Council, 70865201
Available from: 2014-02-27 Created: 2014-02-27 Last updated: 2014-10-06Bibliographically approved

Open Access in DiVA

fulltext(306 kB)408 downloads
File information
File name FULLTEXT01.pdfFile size 306 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full texthttp://www.cell.com

Search in DiVA

By author/editor
Salehpour, MehranPossnert, Göran
By organisation
Department of Physics and Astronomy
In the same journal
Accelerator Physics and InstrumentationBiophysics

Search outside of DiVA

GoogleGoogle Scholar
Total: 408 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 518 hits
ReferencesLink to record
Permanent link

Direct link