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Oxetane modified antisense oligonucleotides promote RNase H cleavage of the complementary RNA strand in the hybrid duplex as efficiently as the native, and offer improved endonuclease resistance
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Faculty of Science and Technology, Biology, Department of Bioorganic Chemistry.
2001 (English)In: JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, ISSN 1472-779X, no 11, 2074-2083 p.Article in journal (Refereed) Published
Abstract [en]

Although the T-m drops similar to6 degreesC/modification (note: T-m loss is similar to 10 degreesC/mismatch) in the oxetane, [1-(1',3'-O-anhydro-beta -D-psicofuranosyl)thymine, (T) under bar], modified antisense (AON)-RNA heteroduplexes, the relative rate

Place, publisher, year, edition, pages
ROYAL SOC CHEMISTRY , 2001. no 11, 2074-2083 p.
Keyword [en]
BIOLOGICAL-ACTIVITY; DNA; TECHNOLOGY; ANALOGS
Identifiers
URN: urn:nbn:se:uu:diva-42161OAI: oai:DiVA.org:uu-42161DiVA: diva2:70062
Note
Addresses: Chattopadhyaya J, Univ Uppsala, Ctr Biomed, Dept Bioorgan Chem, Box 581, S-75123 Uppsala, Sweden Univ Uppsala, Ctr Biomed, Dept Bioorgan Chem, S-75123 Uppsala, SwedenAvailable from: 2008-10-17 Created: 2008-10-17 Last updated: 2011-01-14

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