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Method for immobilization of liposomes in capillary electrophoresis by electrostatic interaction with derivatized agarose
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
Surface Biotechnology. Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Physical and Analytical Chemistry.
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
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2002 (English)In: Electrophoresis, ISSN 3381-3384, Vol. 23, 3381-3384 p.Article in journal (Refereed) Published
Abstract [en]

A novel procedure for immobilization of liposomes inside fused-silica capillaries is

demonstrated. First, the inner wall of the capillaries was coated with a positively

charged polymer, composed of derivatized agarose. Subsequently, negatively charged

liposomes were immobilized by electrostatic interaction on the polymer coating. The

developed liposome coated capillaries were used as a nanoseparation tool for studying

interactions between small drug compounds and liposomes. Part of this work was

presented at the 15th International Symposium on Microscale Separations and Analysis,

HPCE 2002, Stockholm, Sweden, April 2002.

Place, publisher, year, edition, pages
2002. Vol. 23, 3381-3384 p.
Keyword [en]
Capillary electrophoresis; derivatized agarose; electrostatic interaction; immobilized liposomes
Identifiers
URN: urn:nbn:se:uu:diva-42450OAI: oai:DiVA.org:uu-42450DiVA: diva2:70352
Available from: 2007-02-14 Created: 2007-02-14 Last updated: 2011-01-13

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Markides, Karin

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