Legg-Calvé-Perthes disease and the risk of ADHD, depression and mortality: a register study involving 4057 individuals
2014 (English)In: Acta Orthopaedica, ISSN 1745-3674, E-ISSN 1745-3682, Vol. 85, no 5, 501-505 p.Article in journal (Refereed) Published
Background and purpose Hyperactive behavior pattern (such as ADHD) is proposed to be present in individuals with LCPD. We investigated whether individuals with LCPD have a higher risk for ADHD, depression and mortality.
Subjects and methods We identified 4057 individuals with LCPD in Sweden during the period 1964-2011. 40570 individuals without LCPD were randomly selected from the Swedish general population and matched by year of birth, sex and region (control group). We used Cox proportional hazard regression to estimate the relative risks.
Results Compared to the control group, individuals with LCPD had a raised hazard ratio (HR) of 1.5 (95% CI 1.2-1.9) for ADHD. The risks were higher for female (HR=2.1, CI: 1.3-3.5) than for male individuals (HR=1.4, CI: 1.1-1.8). Individuals with LCPD had a modestly higher hazard ratio for depression (HR=1.3, CI: 1.1-1.5) than the control group. Furthermore, individuals with LCPD had a slightly higher mortality risk than the control group (HR=1.2, CI: 1.0-1.4)
Interpretation Individuals with LCPD have a higher risk for ADHD. Hyperactivity could expose the femoral head to higher mechanical stress and contribute to the etiology of LCPD. The higher risk for depression might be due to the burden of LCPD itself or could reflect neurobehavioral aspects of ADHD changing into depression later in life. Individuals with LCPD have a higher mortality risk with higher risk of committing suicide and a slightly higher risk of dying of vascular diseases.
Place, publisher, year, edition, pages
2014. Vol. 85, no 5, 501-505 p.
LCPD, ADHD Depression, Mortality, risk, Epidemiology
Research subject Orthopaedics
IdentifiersURN: urn:nbn:se:uu:diva-219687DOI: 10.3109/17453674.2014.939015ISI: 000342732200009OAI: oai:DiVA.org:uu-219687DiVA: diva2:703807