Exposure to Bisphenol A Affects Lipid Metabolism in Drosophila melanogaster
2014 (English)In: Basic & Clinical Pharmacology & Toxicology, ISSN 1742-7835, E-ISSN 1742-7843, Vol. 114, no 5, 414-420 p.Article in journal (Refereed) Published
Exposure to bisphenol A (BPA) in rodents was shown to induce obesity, yet the mechanism by which BPA might induce obesity is still unclear. We employed the genetically tractable model organism, Drosophila melanogaster, to test the effects of raising them on food containing various concentrations of BPA. Of note, raising males on food containing BPA were susceptible to starvation, possibly by inhibiting their ability to perform lipolysis during starvation, leading to significantly increased lipid content after 24 hr of fasting. Furthermore, feeding males with BPA significantly inhibited the expression of insulin-like peptides. From these results, we conclude that BPA may inhibit lipid recruitment during starvation in Drosophila.
Place, publisher, year, edition, pages
2014. Vol. 114, no 5, 414-420 p.
IdentifiersURN: urn:nbn:se:uu:diva-220148DOI: 10.1111/bcpt.12170ISI: 000333969800007PubMedID: 24215246OAI: oai:DiVA.org:uu-220148DiVA: diva2:704191