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Acute sleep deprivation increases serum levels of neuron-specific enolase (NSE) and S100 calcium binding protein B (S-100B) in healthy young men
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.ORCID iD: 000-0002-8911-4068
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics. (Molekylär geriatrik)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
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2014 (English)In: Sleep, ISSN 0161-8105, E-ISSN 1550-9109, Vol. 37, no 1, 195-198 p.Article in journal (Refereed) Published
Abstract [en]

STUDY OBJECTIVES:

To investigate whether total sleep deprivation (TSD) affects circulating concentrations of neuron-specific enolase (NSE) and S100 calcium binding protein B (S-100B) in humans. These factors are usually found in the cytoplasm of neurons and glia cells. Increasing concentrations of these factors in blood may be therefore indicative for either neuronal damage, impaired blood brain barrier function, or both. In addition, amyloid β (Aβ) peptides 1-42 and 1-40 were measured in plasma to calculate their ratio. A reduced plasma ratio of Aβ peptides 1-42 to 1-40 is considered an indirect measure of increased deposition of Aβ 1-42 peptide in the brain.

DESIGN:

Subjects participated in two conditions (including either 8-h of nocturnal sleep [22:30-06:30] or TSD). Fasting blood samples were drawn before and after sleep interventions (19:30 and 07:30, respectively).

SETTING:

Sleep laboratory.

PARTICIPANTS:

15 healthy young men.

RESULTS:

TSD increased morning serum levels of NSE (P = 0.002) and S-100B (P = 0.02) by approximately 20%, compared with values obtained after a night of sleep. In contrast, the ratio of Aβ peptides 1-42 to 1-40 did not differ between the sleep interventions.

CONCLUSIONS:

Future studies in which both serum and cerebrospinal fluid are sampled after sleep loss should elucidate whether the increase in serum neuron-specific enolase and S100 calcium binding protein B is primarily caused by neuronal damage, impaired blood brain barrier function, or is just a consequence of increased gene expression in non-neuronal cells, such as leukocytes.

Place, publisher, year, edition, pages
2014. Vol. 37, no 1, 195-198 p.
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:uu:diva-220153DOI: 10.5665/sleep.3336ISI: 000332471500021PubMedID: 24470708OAI: oai:DiVA.org:uu-220153DiVA: diva2:704202
Available from: 2014-03-11 Created: 2014-03-11 Last updated: 2017-12-05Bibliographically approved

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Benedict, ChristianCedernaes, JonathanGiedraitis, VilmantasNilsson, Emil KHogenkamp, Pleunie SVågesjö, EvelinaMassena, SaraPettersson, UlrikaChristoffersson, GustafPhillipson, MiaBroman, Jan-ErikLannfelt, LarsSchiöth, Helgi B

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Benedict, ChristianCedernaes, JonathanGiedraitis, VilmantasNilsson, Emil KHogenkamp, Pleunie SVågesjö, EvelinaMassena, SaraPettersson, UlrikaChristoffersson, GustafPhillipson, MiaBroman, Jan-ErikLannfelt, LarsSchiöth, Helgi B
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Functional PharmacologyGeriatricsDepartment of Medical Cell BiologyPsychiatry, University Hospital
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