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Is the rs10484561 SNP responsible for differences in age at diagnosis, transformation and death of patients with follicular lymphoma?
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Oncology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Molecular and Morphological Pathology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Oncology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Oncology.
2013 (English)In: International Journal of Hematologic Oncology, ISSN 2045-1407, Vol. 2, no 5, 391-396 p.Article, review/survey (Refereed) Published
Abstract [en]

Aim:

To analyze follicular lymphoma (FL) patients by determining the genotype at SNP rs10484561 (T or G) and comparing the polymorphism with overall survival, time to transformation, time from transformation to death, and age both dependently and independently of gender.

Materials & methods:A total of 94 patients with FL diagnosed between 1970 and 2000 from a Swedish population were analyzed by PCR–restriction fragment length polymorphism to determine genotypes for rs10484561.

Results:

We found that women with FL and the TT genotype of SNP rs10484561 were older at diagnosis, transformation and when they died (p = 0.03, 0.01 and 0.02, respectively) and had a significantly shorter overall survival (p = 0.04) compared with women with the TG or GG genotypes.

Conclusion:

It is possible that the SNP rs10484561 polymorphism is responsible for differences in age at diagnosis, transformation and death for patients with follicular lymphoma, particularly in women.

Place, publisher, year, edition, pages
2013. Vol. 2, no 5, 391-396 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-220202DOI: 10.2217/ijh.13.48OAI: oai:DiVA.org:uu-220202DiVA: diva2:704438
Available from: 2014-03-12 Created: 2014-03-12 Last updated: 2014-03-12Bibliographically approved

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Berglund, MattiasAmini, Rose-MarieEnblad, GunillaThunberg, Ulf

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