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Social stimulation and corticolimbic reactivity in premenstrual dysphoric disorder: a preliminary study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Obstetrics and Gynaecology. Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology. (Reproduktiv hälsa)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Obstetrics and Gynaecology. (Reproduktiv hälsa/Sundström Poromaa)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology.
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2014 (English)In: Biology of Mood & Anxiety Disorders, ISSN 2045-5380, Vol. 4, no 1, 3- p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND:

Premenstrual dysphoric disorder (PMDD), characterized by luteal phase-induced negative affect and loss of impulse control, often results in compromised social interactions. Although amygdala activation is generally linked to negative affect, increased amygdala reactivity to aversive stimuli in the luteal phase has not been consistently reported in PMDD. We tested the hypothesis that amygdala hyper-reactivity in PMDD is symptom specific, rather than generalized, and linked to socially relevant stimuli. Blood oxygenation level dependent signal changes during exposure to negative images with social and non-social content were evaluated in the mid-follicular and late luteal phase of the menstrual cycle. Fourteen women with PMDD and 13 healthy controls participated.

RESULTS:

When compared with healthy controls, women with PMDD in the luteal phase had enhanced reactivity to social stimuli compared to non-social stimuli in the amygdala and insula, but attenuated reactivity in the anterior cingulate cortex. Functional couplings between emotion processing and controlling areas were significantly different, being positive in women with PMDD and negative in healthy controls. Changes in progesterone levels in women with PMDD correlated positively with altered amygdala reactivity.

CONCLUSIONS:

Socially relevant aversive stimulation elicited enhanced activity in affective processing brain regions that were functionally coupled to compromised activity in cognitive control areas. Because increased reactivity correlated positively with alterations in ovarian steroid levels, data preliminary support the hypothesis that enhanced progesterone sensitivity in PMDD affects corticolimbic processing of social emotions.

Place, publisher, year, edition, pages
2014. Vol. 4, no 1, 3- p.
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-220411DOI: 10.1186/2045-5380-4-3PubMedID: 24572042OAI: oai:DiVA.org:uu-220411DiVA: diva2:704961
Note

De två sista författarna delar sistaförfattarskapet.

Available from: 2014-03-13 Created: 2014-03-13 Last updated: 2017-12-05Bibliographically approved

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Gingnell, MalinBannbers, ElinWikström, JohanSundström-Poromaa, IngerFredrikson, Mats

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Obstetrics and GynaecologyDepartment of PsychologyDepartment of Women's and Children's HealthRadiology
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