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Whole blood and serum concentrations of metals in a Swedish population-based sample
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Endocrine Surgery.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Occupational and Environmental Medicine.ORCID iD: 0000-0002-8949-3555
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
2014 (English)In: Scandinavian Journal of Clinical and Laboratory Investigation, ISSN 0036-5513, E-ISSN 1502-7686, Vol. 74, no 2, 143-148 p.Article in journal (Refereed) Published
Abstract [en]

 Objective

While the potential toxicity of metals in humans is a well-established field of research, there are few studies that examine circulating concentrations of metals in large population-based samples. The aim of this study was to analyze levels of heavy metals and trace elements in both whole blood and serum in an elderly population, and to examine if gender, kidney function, haemoglobin or serum albumin could impact the distribution of metals between whole blood and serum.

Methods

Whole blood and serum samples from 1016 70-year-olds living in Uppsala, Sweden, were analyzed for aluminium, cadmium, cobalt, copper, chromium, mercury, manganese, molybdenum, nickel, lead, and zinc using inductively coupled plasma-sector field mass spectrometry (ICP-SFMS). Distribution between whole blood and serum was evaluated by the ratio between whole blood and serum concentration (B/S-ratio).

Results

Concentrations differed significantly between whole blood and serum measurements for all 11 metals (p < 0.00001). The highest B/S-ratios were found for lead (27), zinc (9), manganese (6), and nickel (4). Copper (0.86), cobalt (0.84), and molybdenum (0.86) showed B/S-ratios < 1. Especially the B/S-ratios for chromium, mercury and nickel correlated with kidney function (GFR) (r = 0.21, - 0.21 and - 0.36 respectively, p < 0.0001).

Conclusions

The distribution between whole blood and serum varied considerably for different metals. This distribution correlated with physiological factors, mainly with kidney function, for several of the metals.

Place, publisher, year, edition, pages
2014. Vol. 74, no 2, 143-148 p.
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:uu:diva-220524DOI: 10.3109/00365513.2013.864785ISI: 000334737700009PubMedID: 24329009OAI: oai:DiVA.org:uu-220524DiVA: diva2:705430
Available from: 2014-03-17 Created: 2014-03-17 Last updated: 2017-12-05Bibliographically approved

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Schultze, BjörnLind, Monica PLarsson, AndersLind, Lars

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