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Neopterin is associated with cardiovascular events and all-cause mortality in renal transplant patients
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2014 (English)In: Clinical Transplantation, ISSN 0902-0063, E-ISSN 1399-0012, Vol. 28, no 1, 111-119 p.Article in journal (Refereed) Published
Abstract [en]

BackgroundInflammatory markers show significant associations with cardiovascular events and all-cause mortality after kidney transplantation. Neopterin, reflecting interferon--release, may better reflect the proinflammatory state of recipients than less specific markers. MethodsKidney transplant recipients in the Assessment of LEscol in Renal Transplant (ALERT) trial were examined and investigated for an association between serum neopterin and subsequent clinical events: graft loss, major cardiovascular events (MACE) and all-cause mortality. ResultsAfter adjustment for established and emerging risk factors neopterin expressed as neopterin-to-creatinine ratio was significantly associated with MACE (p=0.009) and all-cause mortality (p=0.002). Endpoints were more frequent with increasing quartiles of neopterin-to-creatinine ratio. The incidence rates of MACE and all-cause mortality were significantly increased in the upper quartiles compared with the first. ConclusionsThis long-term prospective analysis in stable kidney allograft recipients suggests that neopterin is associated with long-term risk of cardiovascular events and all-cause mortality, but not renal outcomes.

Place, publisher, year, edition, pages
2014. Vol. 28, no 1, 111-119 p.
Keyword [en]
inflammatory marker, kidney transplantation, long-term, neopterin, outcomes
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-220310DOI: 10.1111/ctr.12285ISI: 000330641200015OAI: oai:DiVA.org:uu-220310DiVA: diva2:705502
Available from: 2014-03-17 Created: 2014-03-12 Last updated: 2017-12-05Bibliographically approved

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Fellström, Bengt

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