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ESBL-producing Enterobacteriaceae in Africa: a non-systematic literature review of research published 2008-2012
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, International Maternal and Child Health (IMCH).
2014 (English)In: Infection Ecology & Epidemiology, ISSN 2000-8686, Vol. 4, 20342- p.Article in journal (Refereed) Published
Abstract [en]

Introduction: Enterobacteriaceae producing extended-spectrum beta-lactamases (ESBL) has been found all over the world, and risk factors for acquiring these bacteria involve hospital care and antibiotic treatment. Surveillance studies are present in Europe, North America, and Asia, but there is no summarizing research published on the situation in Africa.

Aim: This review aims to describe the prevalence of ESBL-producing Enterobacteriaceae in hospital and community settings in Africa and the ESBL genes involved. Method: A non-systematic literature search was performed in PubMed. All articles published between 2008 and 2012 were screened and read in full text. Relevant articles were assessed for quality of evidence and included in the review. Articles were divided into regional areas in Africa and tabulated.

Results: ESBL-producing Enterobacteriaceae in hospitalized patients and in communities varies largely between countries and specimens but is common in Africa. ESBLs (class A and D) and plasmid-encoded AmpC (pAmpC) were regularly found, but carbapenemases were also present.

Conclusion: ESBL-producing Enterobacteriaceae in hospital and community settings in Africa is common. Surveillance of antimicrobial resistance needs to be implemented in Africa to tailor interventions targeted at stopping the dissemination of ESBL-producing Enterobacteriaceae.

Place, publisher, year, edition, pages
2014. Vol. 4, 20342- p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-220704DOI: 10.3402/iee.v4.20342OAI: oai:DiVA.org:uu-220704DiVA: diva2:706246
Available from: 2014-03-19 Created: 2014-03-19 Last updated: 2014-03-19Bibliographically approved

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