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Neutrophil gelatinase-associated lipocalin after off pump versus on pump coronary artery surgery
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
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2014 (English)In: Biomarkers, ISSN 1354-750X, Vol. 19, no 1, 22-28 p.Article in journal (Refereed) Published
Abstract [en]

Context: Cardiac surgery. Objective: To compare plasma and urinary neutrophil gelatinase-associated lipocalin (P-/U-NGAL) in on-pump (n = 43) versus off-pump (n = 40) surgery. Materials and methods: We obtained perioperative P-/U-NGAL and outcome data. Results: P-/U-NGAL increased after surgery. P-NGAL was higher post-surgery in on pump patients (139 versus 67 mu g L-1; p<0.001), but not at 24 h. There were no differences in U-NGAL. Correlation between P-/U-NGAL and plasma creatinine was weak. Discussion: P-NGAL acts like a neutrophil activation biomarker and U-NGAL like a tubular injury marker. Conclusion: On-pump patients had greater neutrophil activation. On-versus off-pump surgery had similar impact on tubular cells.

Place, publisher, year, edition, pages
2014. Vol. 19, no 1, 22-28 p.
Keyword [en]
Acute kidney injury, cardiopulmonary bypass, neutrophil activation, NGAL
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-220792DOI: 10.3109/1354750X.2013.863974ISI: 000330885100004OAI: oai:DiVA.org:uu-220792DiVA: diva2:706778
Available from: 2014-03-21 Created: 2014-03-20 Last updated: 2014-03-21Bibliographically approved

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