Tumor Marker Score for Prognostication of Early-stage Squamous Cell Cervical Cancer
2014 (English)In: Anticancer Research, ISSN 0250-7005, Vol. 34, no 2, 887-892 p.Article in journal (Refereed) Published
Background/Aim: Histopathological and clinical scores to predict prognosis in cervical cancer have been of limited value. In the present study a tumor marker expression score was evaluated for prognostication in early-stage cervical cancer. Materials and Methods: The entire study population included 128 women with invasive squamous cell cervical cancer followed-up for at least 10 years. Results: Expression of 12 tumor markers (epidermal growth factor receptor (EGFR), Ki-67, c-MYC, p53, p27, E-cadherin, CD44, vascular endothelial growth factor receptor (VEGF), cyclooxygenase-2 (COX2), CD4, and leucine-rich immunoglobulin-like repeats-1 (LRIG1) and LRIG2, considered relevant for cervical cancer prognostication was evaluated by immunohistochemistry. Expression of five markers, LRIG1, LRIG2, p53, COX2 and c-MYC were useful to make a prognostication score, ranging from 0 to 5. Score 0-1 correlated to less than 5% 10-year mortality, while the mortality rate of those with score 4-5 approached 70%; those with score 2 formed an intermediate group. Using different models, a high sensitivity, specificity, positive predictive value and negative predictive value was attained. Conclusion: Tumor marker scoring could be an adjunct to histopathological and clinical parameters in prognostication of early-stage cervical cancer.
Place, publisher, year, edition, pages
2014. Vol. 34, no 2, 887-892 p.
Cervical cancer, tumor markers, prognosis
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-220995ISI: 000331497200045OAI: oai:DiVA.org:uu-220995DiVA: diva2:707640