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Serum leptin is decreased thirty days after surgery
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
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2014 (English)In: Journal of Diabetes and Metabolism, ISSN 2155-6156, Vol. 5, no 12Article in journal (Refereed) Published
Abstract [en]

Background: Leptin plays an important role for the regulation of food intake, energy expenditure and glucose control. The aim of this study was to study the effect of surgery on circulating levels of human leptin in a human elective surgery model. Methods: A prospective observational study was conducted. Blood sampling was carried out prior to surgery and four and thirty days after elective surgery, respectively. Patients undergoing orthopedic surgery (n=29) and coronary bypass patients (n=21) were included in the study. Serum leptin levels were measured using sandwich ELISA. C-reactive protein (CRP) was analyzed by turbidimetry. Results: Leptin values was significantly decreased thirty days after surgery in both orthopedic (p=0.002) and coronary bypass patients (p=0.003) in comparison with presurgical values. Conclusion: Elective surgery is associated with decreased leptin levels in the late postsurgical phase.

Place, publisher, year, edition, pages
2014. Vol. 5, no 12
National Category
Clinical Medicine Endocrinology and Diabetes
Research subject
Medicine
Identifiers
URN: urn:nbn:se:uu:diva-221276DOI: 10.4172/2155-6156.1000465OAI: oai:DiVA.org:uu-221276DiVA: diva2:708312
Available from: 2014-03-27 Created: 2014-03-27 Last updated: 2016-07-20Bibliographically approved

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Åkerfeldt, TorbjörnLipcsey, MiklosGunningberg, LenaSwenne, Christine, LeoLarsson, Anders

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Clinical MedicineEndocrinology and Diabetes

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