Serum leptin is decreased thirty days after surgery
2014 (English)In: Journal of Diabetes and Metabolism, ISSN 2155-6156, Vol. 5, no 12Article in journal (Refereed) Published
Background: Leptin plays an important role for the regulation of food intake, energy expenditure and glucose control. The aim of this study was to study the effect of surgery on circulating levels of human leptin in a human elective surgery model. Methods: A prospective observational study was conducted. Blood sampling was carried out prior to surgery and four and thirty days after elective surgery, respectively. Patients undergoing orthopedic surgery (n=29) and coronary bypass patients (n=21) were included in the study. Serum leptin levels were measured using sandwich ELISA. C-reactive protein (CRP) was analyzed by turbidimetry. Results: Leptin values was significantly decreased thirty days after surgery in both orthopedic (p=0.002) and coronary bypass patients (p=0.003) in comparison with presurgical values. Conclusion: Elective surgery is associated with decreased leptin levels in the late postsurgical phase.
Place, publisher, year, edition, pages
2014. Vol. 5, no 12
Clinical Medicine Endocrinology and Diabetes
Research subject Medicine
IdentifiersURN: urn:nbn:se:uu:diva-221276DOI: 10.4172/2155-6156.1000465OAI: oai:DiVA.org:uu-221276DiVA: diva2:708312