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Sentinel lymph node biopsy in patients with microinvasive breast cancer: A systematic review and meta-analysis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Oncology.
2014 (English)In: European Journal of Surgical Oncology, ISSN 0748-7983, E-ISSN 1532-2157, Vol. 40, no 1, 5-11 p.Article, review/survey (Refereed) Published
Abstract [en]

Background: The aim of this meta-analysis is to evaluate the role of sentinel lymph node biopsy (SLNB) in patients with microinvasive breast cancer. Methods: We searched MEDLINE and ISI Web of Science to identify studies including patients with microinvasive breast cancer who underwent SLNB and reported the rate of sentinel-node positivity. We performed proportion meta-analysis using either fixed or random-effects model based on the between-study heterogeneity. Findings: A total of 24 studies including 968 patients met the eligibility criteria. The summary estimate for the sentinel-node (SN) positivity rate was 3.2% (95% Confidence Interval (CI): 2.1%-4.6%), 4.0% (95% CI 2.7%-5.5%), and 2.9% (95% CI: 1.6%-4.6%) for macrometastasis, micrometastasis and isolated tumor cells (ITC) respectively. Significant between-study heterogeneity was observed only in the meta-analysis of ITC positivity rate. Interpretation: The amount of positive sentinel node in patients with proven microinvasive breast cancer is relatively low. As a result, the indications for SLNB in these patients should be probably individualized. (C) 2013 Elsevier Ltd. All rights reserved.

Place, publisher, year, edition, pages
2014. Vol. 40, no 1, 5-11 p.
Keyword [en]
Microinvasive, Sentinel node biopsy, Breast cancer, Meta-analysis
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-221185DOI: 10.1016/j.ejso.2013.10.020ISI: 000331414500002OAI: oai:DiVA.org:uu-221185DiVA: diva2:708327
Available from: 2014-03-27 Created: 2014-03-26 Last updated: 2017-12-05Bibliographically approved

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Valachis, Antonis

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