Comparison of post contrast CT urography phases in bladder cancer detection
2016 (English)In: European Radiology, ISSN 0938-7994, E-ISSN 1432-1084, Vol. 26, no 2, 585-591 p.Article in journal (Refereed) Published
Objectives The aim of this study was to investigate which post-contrast phase(s) in a four-phase CT urography protocol is (are) most suitable for bladder cancer detection. Methods The medical records of 106 patients with visible haematuria who underwent a CT urography examination, including unenhanced, enhancement-triggered corticomedullary (CMP), nephrographic (NP) and excretory (EP) phases, were reviewed. The post-contrast phases (n = 318 different phases) were randomized into an evaluation order and blindly reviewed by two uroradiologists. Results Twenty-one patients were diagnosed with bladder cancer. Sensitivity for bladder cancer detection was 0.95 in CMP, 0.83 in NP and 0.81 in EP. Negative predictive value (NPV) was 0.99 in CMP, 0.96 in NP and 0.95 in EP. The sensitivity was higher in CMP than in both NP (p-value 0.016) and EP (p-value 0.0003). NPV was higher in CMP than in NP (p-value 0.024) and EP (p-value 0.002). Conclusion In the CT urography protocol with enhancement-triggered scan, sensitivity and NPV were highest in the corticomedullary phase, and this phase should be used for bladder assessment.
Place, publisher, year, edition, pages
2016. Vol. 26, no 2, 585-591 p.
Multidetector computed tomography; Urography; Urinary bladder neoplasms; Haematuria; Early detection of cancer
Radiology, Nuclear Medicine and Medical Imaging
Research subject Radiology
IdentifiersURN: urn:nbn:se:uu:diva-221282DOI: 10.1007/s00330-015-3844-7ISI: 000368639200034PubMedID: 26002135OAI: oai:DiVA.org:uu-221282DiVA: diva2:708328