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Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
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2014 (English)In: Molecular & Cellular Proteomics, ISSN 1535-9476, E-ISSN 1535-9484, Vol. 13, no 2, 397-406 p.Article in journal (Refereed) Published
Abstract [en]

Global classification of the human proteins with regards to spatial expression patterns across organs and tissues is important for studies of human biology and disease. Here, we used a quantitative transcriptomics analysis (RNA-Seq) to classify the tissue-specific expression of genes across a representative set of all major human organs and tissues and combined this analysis with antibody-based profiling of the same tissues. To present the data, we launch a new version of the Human Protein Atlas that integrates RNA and protein expression data corresponding to ∼80% of the human protein-coding genes with access to the primary data for both the RNA and the protein analysis on an individual gene level. We present a classification of all human protein-coding genes with regards to tissue-specificity and spatial expression pattern. The integrative human expression map can be used as a starting point to explore the molecular constituents of the human body.

Place, publisher, year, edition, pages
2014. Vol. 13, no 2, 397-406 p.
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Medical and Health Sciences
URN: urn:nbn:se:uu:diva-221324DOI: 10.1074/mcp.M113.035600ISI: 000331369000002PubMedID: 24309898OAI: oai:DiVA.org:uu-221324DiVA: diva2:708569
Available from: 2014-03-28 Created: 2014-03-28 Last updated: 2015-11-20Bibliographically approved

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Kampf, CarolineDjureinovic, DijanaDanielsson, AngelikaEdlund, KarolinaAsplund, AnnaSjöstedt, EvelinaLindskog, CeciliaOlsson, IngMariePontén, Fredrik
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Department of Immunology, Genetics and Pathology
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Molecular & Cellular Proteomics
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