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Targeting the PDGF Signaling Pathway in the Treatment of Non-Malignant Diseases.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research. Uppsala University, Science for Life Laboratory, SciLifeLab.
2014 (English)In: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, ISSN 1557-1904, Vol. 9, no 2, 69-79 p.Article in journal (Refereed) Published
Abstract [en]

Platelet-derived growth factor (PDGF) is a family of mesenchymal mitogens with important functions during the embryonal development and in the control of tissue homeostasis in the adult. The PDGF isoforms exert their effects by binding to α-and β-tyrosine kinase receptors. Overactivity of PDGF signaling has been linked to the development of certain malignant and non-malignant diseases, including atherosclerosis and various fibrotic diseases. Different types of PDGF antagonists have been developed, including inhibitory monoclonal antibodies and DNA aptamers against PDGF isoforms and receptors, and receptor tyrosine kinase inhibitors. Beneficial effects have been recorded using such inhibitors in preclinical models and in patients with certain malignant as well as non-malignant diseases. The present communication summarizes the use of PDGF antagonists in the treatment of non-malignant diseases.

Place, publisher, year, edition, pages
2014. Vol. 9, no 2, 69-79 p.
National Category
Basic Medicine
URN: urn:nbn:se:uu:diva-221530DOI: 10.1007/s11481-013-9484-2ISI: 000333122000002PubMedID: 23793451OAI: oai:DiVA.org:uu-221530DiVA: diva2:709288
Available from: 2014-04-01 Created: 2014-04-01 Last updated: 2014-04-23Bibliographically approved

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Heldin, Carl-Henrik
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Ludwig Institute for Cancer ResearchScience for Life Laboratory, SciLifeLab
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