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Antibiotic resistance patterns in Escherichia coli from gulls in nine European countries
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Microbiology and Infectious Medicine.
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2014 (English)In: Infection Ecology & Epidemiology, ISSN 2000-8686, Vol. 4, 21565- p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: The prevalence of antibiotic resistant faecal indicator bacteria from humans and food production animals has increased over the last decades. In Europe, resistance levels in Escherichia coli from these sources show a south-to-north gradient, with more widespread resistance in the Mediterranean region compared to northern Europe. Recent studies show that resistance levels can be high also in wildlife, but it is unknown to what extent resistance levels in nature conform to the patterns observed in human-associated bacteria.

METHODS: To test this, we collected 3,158 faecal samples from breeding gulls (Larus sp.) from nine European countries and tested 2,210 randomly isolated E. coli for resistance against 10 antibiotics commonly used in human and veterinary medicine.

RESULTS: Overall, 31.5% of the gull E. coli isolates were resistant to ≥1 antibiotic, but with considerable variation between countries: highest levels of isolates resistant to ≥1 antibiotic were observed in Spain (61.2%) and lowest levels in Denmark (8.3%). For each tested antibiotic, the Iberian countries were either the countries with the highest levels or in the upper range in between-country comparisons, while northern countries generally had a lower proportion of resistant E. coli isolates, thereby resembling the gradient of resistance seen in human and food animal sources.

CONCLUSION: We propose that gulls may serve as a sentinel of environmental levels of antibiotic resistant E. coli to complement studies of human-associated microbiota.

Place, publisher, year, edition, pages
2014. Vol. 4, 21565- p.
National Category
Basic Medicine
URN: urn:nbn:se:uu:diva-221852DOI: 10.3402/iee.v4.21565PubMedID: 24427451OAI: oai:DiVA.org:uu-221852DiVA: diva2:710175
Available from: 2014-04-04 Created: 2014-04-04 Last updated: 2014-09-10Bibliographically approved

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Hasan, BadrulOlsen, BjörnDrobni, Mirva
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