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Anthroposophic lifestyle and salivary cortisol are associated with a lower risk of sensitization during childhood
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Child and Adolescent Psychiatry.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Child and Adolescent Psychiatry.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Child and Adolescent Psychiatry.
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2015 (English)In: Pediatric Allergy and Immunology, ISSN 0905-6157, E-ISSN 1399-3038, Vol. 26, no 2, 153-160 p.Article in journal (Refereed) Published
Abstract [en]

Background

Infants from anthroposophic families have low cortisol levels and low risk of IgE-sensitization during first 2 years of life. Our aim is to study the impact of an anthroposophic lifestyle and cortisol levels at 6 months on allergy sensitization up to age 5 years.

Methods

507 families participated from maternal health care centers. Parental lifestyle was categorized as Anthroposophic, Partly anthroposophic or Non-anthroposophic. Blood samples for analyzes of sensitization were obtained from parents at inclusion and from children at 6, 12, 24 and 60 months. Salivary samples were collected at home at 6 months.

Results

Sensitization increased from 2.9 to 26.0% in the anthroposophic group, from 8.4 to 26.8% in the partly anthroposophic group and from 19.1 to 44.1% in the non-anthroposophic group. Children from anthroposophic families had lower cortisol levels in the morning, afternoon and evening. The odds ratio (OR) for anthroposophic lifestyle was always <1 and lowest at 12 months (OR, 0.10; 95% CI, 0.03-0.36). Adjusting for cortisol levels at 6 months increased these ORs at 12 and 24 months. At the same ages ORs for sensitization were elevated also for cortisol levels at 6 months. Analyzes in children not sensitized at 6 months confirmed the cortisol-related risk of sensitization.

Conclusions

Children from families with an anthroposophic lifestyle have lower risk than comparisons of developing sensitization up to 5 years. This risk is partially explained by low cortisol levels during infancy. High cortisol levels at 6 months predict sensitization up to 24 months.

Place, publisher, year, edition, pages
2015. Vol. 26, no 2, 153-160 p.
National Category
Pediatrics
Identifiers
URN: urn:nbn:se:uu:diva-221953DOI: 10.1111/pai.12342ISI: 000351626800011OAI: oai:DiVA.org:uu-221953DiVA: diva2:710468
Available from: 2014-04-07 Created: 2014-04-07 Last updated: 2017-12-05Bibliographically approved

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Swartz, JackieLindblad, FrankArinell, Hans

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