Anthroposophic lifestyle and salivary cortisol are associated with a lower risk of sensitization during childhood
2015 (English)In: Pediatric Allergy and Immunology, ISSN 0905-6157, E-ISSN 1399-3038, Vol. 26, no 2, 153-160 p.Article in journal (Refereed) Published
Infants from anthroposophic families have low cortisol levels and low risk of IgE-sensitization during first 2 years of life. Our aim is to study the impact of an anthroposophic lifestyle and cortisol levels at 6 months on allergy sensitization up to age 5 years.
507 families participated from maternal health care centers. Parental lifestyle was categorized as Anthroposophic, Partly anthroposophic or Non-anthroposophic. Blood samples for analyzes of sensitization were obtained from parents at inclusion and from children at 6, 12, 24 and 60 months. Salivary samples were collected at home at 6 months.
Sensitization increased from 2.9 to 26.0% in the anthroposophic group, from 8.4 to 26.8% in the partly anthroposophic group and from 19.1 to 44.1% in the non-anthroposophic group. Children from anthroposophic families had lower cortisol levels in the morning, afternoon and evening. The odds ratio (OR) for anthroposophic lifestyle was always <1 and lowest at 12 months (OR, 0.10; 95% CI, 0.03-0.36). Adjusting for cortisol levels at 6 months increased these ORs at 12 and 24 months. At the same ages ORs for sensitization were elevated also for cortisol levels at 6 months. Analyzes in children not sensitized at 6 months confirmed the cortisol-related risk of sensitization.
Children from families with an anthroposophic lifestyle have lower risk than comparisons of developing sensitization up to 5 years. This risk is partially explained by low cortisol levels during infancy. High cortisol levels at 6 months predict sensitization up to 24 months.
Place, publisher, year, edition, pages
2015. Vol. 26, no 2, 153-160 p.
IdentifiersURN: urn:nbn:se:uu:diva-221953DOI: 10.1111/pai.12342ISI: 000351626800011OAI: oai:DiVA.org:uu-221953DiVA: diva2:710468