uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Hemodynamic effects of the use of oral snuff
Departments of Oral Surgery, Clinical Pharmacology, and Pulmonary Medicine, Sahlgrens University Hospital, Göteborg, Sweden.
Show others and affiliations
1992 (English)In: Clinical Pharmacology and Therapeutics, ISSN 0009-9236, E-ISSN 1532-6519, Vol. 52, no 4, 394-401 p.Article in journal (Refereed) Published
Abstract [en]

The hemodynamic effects during rest and exercise of oral snuff were investigated in an open, placebo-controlled study of nine habitual users of oral snuff. Blood pressure, heart rate, and central hemodynamics were measured noninvasively. Plasma concentrations of nicotine, cotinine, norepinephrine, and epinephrine, as well as neuropeptide Y-like immunoreactivity were measured before and after snuff intake during rest and exercise. Snuff intake induced a significant increase in heart rate and blood pressure and a decrease in stroke volume during rest. Hemodynamic changes were unrelated to nicotine or cotinine concentrations. Resting levels of norepinephrine and neuropeptide Y-like immunoreactivity were similar with or without snuff, whereas epinephrine was slightly increased 30 minutes after snuff intake. The exercise-induced increase in norepinephrine and neuropeptide Y-like immunoreactivity did not differ between the days subjects received snuff and the days they received placebo. In contrast, maximum work load was associated with a slight increase in circulating epinephrine after snuff intake. The findings suggest that snuff intake is associated with significant hemodynamic effects during rest but not during exercise. These effects could not be readily explained by activation of the sympathetic nervous system.

Place, publisher, year, edition, pages
1992. Vol. 52, no 4, 394-401 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-222057DOI: 10.1038/clpt.1992.161PubMedID: 1424411OAI: oai:DiVA.org:uu-222057DiVA: diva2:710608
Available from: 2014-04-07 Created: 2014-04-07 Last updated: 2014-11-04Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Hirsch, Jan M
In the same journal
Clinical Pharmacology and Therapeutics
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 165 hits
ReferencesLink to record
Permanent link

Direct link