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Reactivated herpes simplex virus infection as a possible cause of dry socket after tooth extraction
Department of Oral Surgery, University of Göteborg, Sweden.
1993 (English)In: Journal of oral and maxillofacial surgery (Print), ISSN 0278-2391, E-ISSN 1531-5053, Vol. 51, no 4, 370-376; discussion 377 p.Article in journal (Refereed) Published
Abstract [en]

This study was designed to evaluate a possible association between reactivated herpes simplex virus type 1 (HSV-1) infection after lower third molar extraction and development of dry socket (DS). The HSV-1 antibody response was analyzed before and after tooth removal by enzyme-linked immunosorbent assay and immunoblotting in 208 patients. History of previous possible oral herpes reactivation was evaluated by a questionnaire that was based on self-rated frequency of oral cold sores. Tobacco users were identified. The anatomic proximity of the root apex to the mandibular nerve canal was classified radiographically before extraction. Fifteen patients (7%) developed DS after tooth extraction. Eleven of the 15 DS patients (73%) were HSV seropositive as compared with 7 of 15 (47%) in the matched control group. Seven of the 11 seropositive DS patients have shown HSV-1 reactivation by an increase of specific polypeptides, predominantly gB, gC, gD and ICP 4 and 6, in the immunoblot test. No change in HSV-1 reactivity was observed in control sera. DS patients reported a high frequency of oral cold sores (64%) compared with the controls (33%). Tobacco use was not found to influence the frequency of cold sores or the development of DS. A close radiographic proximity between the mandibular canal and root apex was more common (P < .05) in DS patients. The results indicate that extraction of a mandibular third molar could be a possible cause of reactivation and recurrence of an HSV-1 infection. The serum antibody response, the anatomical nerve/root proximity, and the history of oral cold sores reflect an association between HSV-1 and DS after tooth extraction.

Place, publisher, year, edition, pages
1993. Vol. 51, no 4, 370-376; discussion 377 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-222058DOI: 10.1016/S0278-2391(10)80347-7PubMedID: 8450353OAI: oai:DiVA.org:uu-222058DiVA: diva2:710610
Available from: 2014-04-07 Created: 2014-04-07 Last updated: 2014-11-04Bibliographically approved

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Hirsch, Jan M
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