Hypertriglyceridemic Waist Phenotype Is Associated with Decreased Insulin Sensitivity and Incident Diabetes in Elderly Men
2014 (English)In: Obesity, ISSN 1930-7381, Vol. 22, no 2, 526-529 p.Article in journal (Refereed) Published
Objective: To investigate the association between hypertriglyceridemic waist (HTGW) and insulin sensitivity (assessed by euglycemic clamp method), and the development of diabetes in a longitudinal community-based cohort of elderly men without diabetes at baseline. Design and Methods: The present cross-sectional study comprised 1,026, 70-year-old men without diabetes. The gold standard euglycaemic-hyperinsulinaemic clamp technique was used. Six-year follow-up on diabetes status were available in n = 667. The HTGW phenotype was defined as having waist circumference >= 90 cm, and triglycerides >= 2 mmol L-1. The men were stratified into those having normal WC and TG (n = 299), one HTGW component (n = 606), and HTGW (n = 121). Results: The association between insulin sensitivity and one HTGW component as well as HTGW was highly significant (P < 0.001) in the whole sample, as well as in individuals with high/low BMI (stratified at >= 25). In longitudinal analyses, participants with HTGW was associated with a more than fourfold increased risk for diabetes (Odds ratio 4.64, 95% CI 1.61-13.4, P = 0.004) compared to those with normal WC and TG. Conclusion: The present study both confirm and extend previous research suggesting that the HTGW-phenotype portrays an increased glucometabolic risk, also in lean individuals.
Place, publisher, year, edition, pages
2014. Vol. 22, no 2, 526-529 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-221971DOI: 10.1002/oby.20434ISI: 000332224200029OAI: oai:DiVA.org:uu-221971DiVA: diva2:710939