Circulating levels of p,p '-DDE are related to prevalent hypertension in the elderly
2014 (English)In: Environmental Research, ISSN 0013-9351, E-ISSN 1096-0953, Vol. 129, 27-31 p.Article in journal (Refereed) Published
Background: Polychlorinated biphenyls (PCBs) and dioxin given to experimental animals increase the blood pressure. We therefore investigated if circulating levels of persistent organic pollutants (POPs) were related to hypertension in a population-based sample of men and women. Methods: One thousand and sixteen subjects aged 70 years were investigated in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. Twenty-three POPs were analyzed using high-resolution gas chromatography/high-resolution mass spectrometry (HRGC/HRMS). Hypertension was defined as a systolic blood pressure >= 140 mmHg or a diastolic blood pressure >= 90 mmHg, and/or use of antihypertensive medication. Results: Seven hundred and thirty-two subjects (72%) showed hypertension. When the POPs were treated as continuous variables and adjusted for gender only, two PCBs with a low number of chlorine atoms (PCB 105 and 118) were related to prevalent hypertension. Also the OC pesticide p,p'-DDE was related to hypertension. The strongest of these associations was seen for p,p'-DDE (OR 135 for a 1 SD change, 95% CI 1.17-1.56, p < 0.0001). Following further adjustment also for BMI, smoking status, education level and exercise habits, only p,p'-DDE was still significantly related to hypertension (OR 1.23 for a 1 SD change, 95% CI 1.06-1.43, p=0.006). Conclusion: In this cross-sectional analysis of an elderly population, high levels of circulating levels of p,p'-DDE were associated with prevalent hypertension, further strengthening the experimental findings that POPs might influence blood pressure.
Place, publisher, year, edition, pages
2014. Vol. 129, 27-31 p.
Hypertension, Elderly, Persistent organic pollutants, Polychlorinated biphenyls, DDE
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-222205DOI: 10.1016/j.envres.2013.12.003ISI: 000331921100004OAI: oai:DiVA.org:uu-222205DiVA: diva2:711188