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Periodical solutions in a pulse-modulated model of endocrine regulation with time-delay
Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Systems and Control. Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Automatic control.
Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Systems and Control. Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Automatic control.
2014 (English)In: IEEE Transactions on Automatic Control, ISSN 0018-9286, E-ISSN 1558-2523, Vol. 59, no 3, 728-733 p.Article in journal (Refereed) Published
Place, publisher, year, edition, pages
2014. Vol. 59, no 3, 728-733 p.
National Category
Control Engineering
Identifiers
URN: urn:nbn:se:uu:diva-222396DOI: 10.1109/TAC.2013.2273284ISI: 000332037800013OAI: oai:DiVA.org:uu-222396DiVA: diva2:711623
Available from: 2014-02-19 Created: 2014-04-10 Last updated: 2017-12-05Bibliographically approved
In thesis
1. Pulse-modulated feedback in mathematical modeling and estimation of endocrine systems
Open this publication in new window or tab >>Pulse-modulated feedback in mathematical modeling and estimation of endocrine systems
2014 (English)Licentiate thesis, comprehensive summary (Other academic)
Abstract [en]

The research field of systems biology has gained a lot of interest during the last decades. Systems biology can be seen as the systematic study of complex interactions in biological systems, mainly by methods from dynamical systems theory. This thesis mainly deals with the testosterone (Te) regulation in the human male, but techniques developed here might be useful for studying other parts of the endocrine system too. The contribution of the thesis can be divided into two parts: one covering mathematical models of Te regulation and another suggesting and validating identification techniques for those models. Regarding modeling, existing models of testosterone regulation have been extended with time delays and nonlinear dynamics, with the purpose of achieving better fit to clinical data. The identification part treats the estimation of unknown model parameters, and estimation of signals that cannot be measured in a noninvasive way.

Place, publisher, year, edition, pages
Uppsala University, 2014
Series
Information technology licentiate theses: Licentiate theses from the Department of Information Technology, ISSN 1404-5117 ; 2014-006
National Category
Control Engineering
Research subject
Electrical Engineering with specialization in Automatic Control
Identifiers
urn:nbn:se:uu:diva-231908 (URN)
Presentation
2014-09-09, Room 2003, Ångströmlaboratoriet, Lägerhyddsvägen 1, Uppsala, 10:15 (English)
Supervisors
Available from: 2014-09-09 Created: 2014-09-10 Last updated: 2017-08-31Bibliographically approved

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Medvedev, AlexanderMattsson, Per

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