uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Familial effects on ischemic stroke: the role of sibling kinship, sex, and age of onset
Show others and affiliations
2012 (English)In: Circulation: Cardiovascular Genetics, ISSN 1942-325X, Vol. 5, no 2, 226-233 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Previous studies on familial risk of ischemic stroke have supported genetic influence on the disease incidence. This study aimed to characterize these familial effects in a nationwide population-based study by taking into account sibling relations, sex of siblings, and age of onset, with respect to ischemic stroke incidence.

METHODS AND RESULTS: Incident ischemic stroke cases identified from the Swedish Hospital Discharge and Cause of Death Registers between 1987 and 2007 were linked to their stroke-free siblings (study participants), forming an exposed sib-pair. Each exposed sib-pair was matched up to 5 unexposed sib-pairs from the Multi-Generation Registry by birth and calendar years. Incident ischemic stroke risk was assessed using hazard estimates obtained from stratified Cox regression analyses. A total of 30 735 exposed and 152 391 unexposed study participants were included in the analyses. The overall risk of incident ischemic stroke when exposed was significantly increased (relative risk, 1.61; 95% confidence interval, 1.48-1.75; P<0.001). Familial risk was higher in full (relative risk, 1.64; 95% confidence interval, 1.50-1.81; P<0.001) than in half (relative risk, 1.41; 95% confidence interval, 1.10-1.82; P=0.007) siblings. Familial risk of early ischemic stroke almost doubled when exposed to early ischemic stroke (relative risk, 1.94; 95% confidence interval, 1.41-2.67; P<0.001).

CONCLUSIONS: There was a 60% increased risk for ischemic stroke in individuals having a sibling with prior stroke. The familial effect was even higher for full-sibling relations. Familial effects were observed in both male and female individuals, and no differential effects depending on the sex of either of the siblings were found.

Place, publisher, year, edition, pages
2012. Vol. 5, no 2, 226-233 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-223043DOI: 10.1161/CIRCGENETICS.111.962241PubMedID: 22407453OAI: oai:DiVA.org:uu-223043DiVA: diva2:712712
Available from: 2014-04-16 Created: 2014-04-16 Last updated: 2016-01-25Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Ingelsson, Erik
In the same journal
Circulation: Cardiovascular Genetics
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 181 hits
ReferencesLink to record
Permanent link

Direct link