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Re-evaluation of clinical dementia diagnoses with pittsburgh compound B positron emission tomography
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Section of Nuclear Medicine and PET.
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2013 (English)In: Dementia and geriatric cognitive disorders extra, ISSN 1664-5464, Vol. 3, no 1, 472-481 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES:

There is an overlap regarding Pittsburgh compound B (PIB) retention in patients clinically diagnosed as Alzheimer's disease (AD) and non-AD dementia. The aim of the present study was to investigate whether there are any differences between PIB-positive and PIB-negative patients in a mixed cohort of patients with neurodegenerative dementia of mild severity regarding neuropsychological test performance and regional cerebral glucose metabolism measured with [(18)F]fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET).

METHODS:

Eighteen patients clinically diagnosed as probable AD or frontotemporal dementia were examined with PIB PET, FDG PET and neuropsychological tests and followed for 5-9 years in a clinical setting.

RESULTS:

The PIB-positive patients (7 out of 18) had slower psychomotor speed and more impaired visual episodic memory than the PIB-negative patients; otherwise performance did not differ between the groups. The initial clinical diagnoses were changed in one third of the patients (6 out of 18) during follow-up.

CONCLUSIONS:

The subtle differences in neuropsychological performance, the overlap of hypometabolic patterns and clinical features between AD and non-AD dementia highlight the need for amyloid biomarkers and a readiness to re-evaluate the initial diagnosis.

Place, publisher, year, edition, pages
2013. Vol. 3, no 1, 472-481 p.
National Category
Geriatrics
Identifiers
URN: urn:nbn:se:uu:diva-223235DOI: 10.1159/000356273PubMedID: 24516415OAI: oai:DiVA.org:uu-223235DiVA: diva2:712882
Available from: 2014-04-16 Created: 2014-04-16 Last updated: 2014-06-05Bibliographically approved

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Degerman Gunnarsson, MalinWall, AndersLannfelt, LarsBasun, HansKilander, Lena

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