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Normal outcome of pregnancy with ongoing treatment with natalizumab
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neurology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neurology.ORCID iD: 0000-0002-7045-1806
2014 (English)In: Acta Neurologica Scandinavica, ISSN 0001-6314, E-ISSN 1600-0404, Vol. 129, no 6, e27-e29 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Treatment of multiple sclerosis (MS) with natalizumab during pregnancy is not recommended due to potential risks for the foetus. Despite strong advice accidental pregnancies occur.

CASE: A 32-year old woman with MS since the age of 26 was treated with natalizumab since January 2008. Treatment was stopped April 2011 due to pregnancy plans, but was restarted following an MS relapse. The patient was thoroughly informed about potential foetal risks, but nevertheless she one year later disclosed that she was pregnant in gestational week 15. Treatment was continued, since the first trimester had passed. The pregnancy course was normal and a healthy daughter was born at full gestational term.

CONCLUSIONS: This is the second known case where natalizumab treatment continued throughout the whole gestational period.

Place, publisher, year, edition, pages
2014. Vol. 129, no 6, e27-e29 p.
National Category
Neurology
Identifiers
URN: urn:nbn:se:uu:diva-223633DOI: 10.1111/ane.12222ISI: 000333851500001PubMedID: 24527849OAI: oai:DiVA.org:uu-223633DiVA: diva2:713492
Available from: 2014-04-23 Created: 2014-04-23 Last updated: 2017-12-05Bibliographically approved

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Fagius, JanBurman, Joachim

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