Impact of sex on perinatal mortality and morbidity in twins
2014 (English)In: Journal of Perinatal Medicine, ISSN 0300-5577, E-ISSN 1619-3997, Vol. 42, no 2, 225-231 p.Article in journal (Refereed) Published
Objective: Twin studies offer opportunities to investigate mechanisms underlying sex-associated differences in perinatal outcomes. The objective of the study was to investigate sex-related differences in perinatal complications. Study design: A cohort of 16,045 twin pregnancies 32,090 twins - was explored for obstetric complications, perinatal and infant mortality, and neonatal morbidities. Results: Twin pregnancies with a female fetus had an increased risk for preeclampsia, but otherwise there were no pregnancy complications associated with fetal sex. After birth, female-female twins had lower early neonatal and infant mortality, and lower risk for respiratory morbidities than male-male twins at all gestational ages. In unlike-sexed twin pairs, very preterm males had higher respiratory morbidity than females and, females were at higher risk for being growth restricted. Conclusion: Male-male twins have higher respiratory morbidity and neonatal mortality than female-female twins. In unliked-sexed twin pairs, the males seem to be protected by having a female co-twin.
Place, publisher, year, edition, pages
2014. Vol. 42, no 2, 225-231 p.
Growth restriction, newborn, respiratory morbidity, preeclampsia, preterm
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-223545DOI: 10.1515/jpm-2013-0147ISI: 000332843500011OAI: oai:DiVA.org:uu-223545DiVA: diva2:713577