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The age and genomic integrity of neurons after cortical stroke in humans
Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics. (Jonfysik)
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2014 (English)In: Nature Neuroscience, ISSN 1097-6256, Vol. 17, no 6, 801-803 p.Article in journal (Refereed) Published
Abstract [en]

It has been unclear whether ischemic stroke induces neurogenesis or neuronal DNA rearrangements in the human neocortex. Using immunohistochemistry; transcriptome, genome and ploidy analyses; and determination of nuclear bomb test-derived (14)C concentration in neuronal DNA, we found neither to be the case. A large proportion of cortical neurons displayed DNA fragmentation and DNA repair a short time after stroke, whereas neurons at chronic stages after stroke showed DNA integrity, demonstrating the relevance of an intact genome for survival.

Place, publisher, year, edition, pages
2014. Vol. 17, no 6, 801-803 p.
Keyword [en]
Neurogenesis, cell regeneration, cortical stroke, bomb peak
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URN: urn:nbn:se:uu:diva-223754DOI: 10.1038/nn.3706ISI: 000336638000013PubMedID: 24747576OAI: oai:DiVA.org:uu-223754DiVA: diva2:713942
Available from: 2014-04-24 Created: 2014-04-24 Last updated: 2014-07-02Bibliographically approved

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Salehpour, MehranPossnert, Göran
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