uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Efficacy and safety of rituximab as maintenance therapy for relapsing granulomatosis with polyangiitis-a case series.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Rheumatology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Rheumatology.
2014 (English)In: Clinical Rheumatology, ISSN 0770-3198, E-ISSN 1434-9949, Vol. 33, no 6, 841-848 p.Article in journal (Refereed) Published
Abstract [en]

The objective of this work was to study the efficacy and safety of pre-emptive rituximab (RTX) in a series of patients with severe relapsing granulomatosis with polyangiitis (GPA). GPA is a systemic vasculitis with a high relapse rate despite successful remission induction. Drug toxicity with repeated induction treatments and long-standing immunosuppression poses a problem. Based on the findings in reports on RTX for rheumatoid arthritis, we treated patients with severe relapsing GPA with pre-emptive RTX, 1,000 mg 2 weeks apart every 6 months, aiming at achieving sustainable remission. All patients at one centre with relapsing GPA in spite of traditional maintenance treatment, who had received more than or equal to three cycles of RTX as regularly repeated pre-emptive maintenance therapy every 6 months, were included in this retrospective study. Information on disease manifestations and activity, treatments, lab parameters and adverse events was extracted from the medical files. Of the 12 included patients, all with a positive proteinase 3-anti-neutrophil cytoplasmic antibodies, generalised disease and a median disease duration of 35 months (21-270), 92 % (11/12) achieved sustainable remission during a median follow-up time of 32 months (range 21-111) from first RTX treatment. Concomitant immunosuppressants were reduced. Infections were the most common adverse events, but infections were an issue also before the start of RTX. RTX administered every 6 months seems to be an effective maintenance treatment in a population with severe, relapsing long-standing GPA. Granulomatous as well as vasculitic manifestations responded equally well. Infections are a problem in this patient group but no new safety problems were identified.

Place, publisher, year, edition, pages
2014. Vol. 33, no 6, 841-848 p.
National Category
Rheumatology and Autoimmunity
Identifiers
URN: urn:nbn:se:uu:diva-223823DOI: 10.1007/s10067-013-2351-yISI: 000338323800016PubMedID: 23959445OAI: oai:DiVA.org:uu-223823DiVA: diva2:714327
Available from: 2014-04-27 Created: 2014-04-27 Last updated: 2017-12-05Bibliographically approved

Open Access in DiVA

fulltext(189 kB)78 downloads
File information
File name FULLTEXT01.pdfFile size 189 kBChecksum SHA-512
27de6a1a55eff8673b92d32c675e66ee121d0506d3ee1901e0c2fe69982f1f7a5dad4fefa8a1e39a1ef45292a8487bbe4deaaed7997aa1252335993a3c7f14cf
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records BETA

Knight, ABaecklund, Eva

Search in DiVA

By author/editor
Knight, ABaecklund, Eva
By organisation
RheumatologyDepartment of Pharmaceutical Biosciences
In the same journal
Clinical Rheumatology
Rheumatology and Autoimmunity

Search outside of DiVA

GoogleGoogle Scholar
Total: 78 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 399 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf