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Bioavailability of cinnarizine in dogs: effect of SNEDDS loading level and correlation with cinnarizine solubilization during in vitro lipolysis
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2013 (English)In: Pharmaceutical research, ISSN 0724-8741, E-ISSN 1573-904X, Vol. 30, no 12, 3101-3113 p.Article in journal (Refereed) Published
Abstract [en]

PURPOSE: To investigate the effect of increasing the loading level of the poorly soluble drug cinnarizine in a self-nanoemulsifying drug delivery system (SNEDDS) both in vitro and in vivo.

METHODS: A fixed dose of cinnarizine was administered orally to dogs in solution in different amounts of SNEDDS vehicle. Furthermore, the SNEDDSs were characterised using the dynamic in vitro lipolysis model.

RESULTS: Statistical differences in bioavailability were not obtained between the different amounts of SNEDDS vehicle, in spite of differences in the tendency of cinnarizine to precipitate during in vitro lipolysis of the treatments. Use of the SNEDDS concept decreased the variation in cinnarizine exposure observed between dogs as compared to administering cinnarizine in an aqueous suspension.

CONCLUSIONS: Optimization of SNEDDSs towards keeping the drug compound in solution upon in vitro lipolysis of the SNEDDSs may not be as important as previously suggested.

Place, publisher, year, edition, pages
2013. Vol. 30, no 12, 3101-3113 p.
National Category
Basic Medicine
Identifiers
URN: urn:nbn:se:uu:diva-223953DOI: 10.1007/s11095-013-1145-xPubMedID: 23949249OAI: oai:DiVA.org:uu-223953DiVA: diva2:714535
Available from: 2014-04-28 Created: 2014-04-28 Last updated: 2017-12-05Bibliographically approved

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Abrahamsson, Bertil

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