Pathologic conditions associated with elevated plasma soluble transferrin receptor levels in elderly iron replete anemic patients
2010 (English)In: International journal of hematology, ISSN 0925-5710, E-ISSN 1865-3774, Vol. 91, no 4, 723-724 p.Article in journal (Refereed) Published
Iron-deficiency anemia (IDA) in men and post-menopausal women is commonly caused by an imbalance between dietary iron absorption and blood loss via the gastrointestinal tract. In younger, otherwise healthy individuals IDA is accompanied by typical changes in the biochemical iron status, i.e. iron, ferritin and transferrin saturation (TSAT) are subnormal, whereas total iron binding capacity (TIBC) is increased . In elderly anemic patients who may suffer from concurrent diseases, e.g. infections, inflammatory diseases or cancer, the biochemical iron status is often difficult to interpret since it is influenced by acute phase responses . Anemia induced by an inflammatory response is commonly referred to as anemia of chronic disease (ACD) and characterized by a blockage of iron in the reticuloendothelial system. A bone marrow examination is often required to discriminate between IDA and ACD in elderly patients with concurrent diseases. IDA is characterized by the absence of stainable.
Place, publisher, year, edition, pages
2010. Vol. 91, no 4, 723-724 p.
IdentifiersURN: urn:nbn:se:uu:diva-223960DOI: 10.1007/s12185-010-0564-2PubMedID: 20387132OAI: oai:DiVA.org:uu-223960DiVA: diva2:714574