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Iron-restricted erythropoiesis in anaemic patients with giant cell arteritis and polymyalgia rheumatica
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Haematology.
2013 (English)In: Open journal of blood diseases, ISSN 2164-3199, Vol. 3, 49-52 p.Article in journal (Refereed) Published
Abstract [en]

The aim of this observational study was to biochemically characterize the anaemia in GCA (giant cell arteritis) and PMR (polymyalgia rheumatica) patients. Values for mean corpuscular volume, mean corpuscular hemoglobin and solu- ble transferrin receptor were normal, whereas serum iron and total iron binding capacity (TIBC) were subnormal, and mean ferritin was above the upper reference limit. Iron-restricted erythropoiesis (IRE), defined as a bone marrow smear staining positive for iron in combination with transferrin saturation less than 20%, was present in all patients. All pa- tients exhibited clinical and biochemical signs of active inflammation with elevated C-reactive protein and an increased erythrocyte sedimentation rate.

Place, publisher, year, edition, pages
2013. Vol. 3, 49-52 p.
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Clinical Medicine
Identifiers
URN: urn:nbn:se:uu:diva-223966DOI: 10.4236/ojbd.2013.31010OAI: oai:DiVA.org:uu-223966DiVA: diva2:714596
Available from: 2014-04-28 Created: 2014-04-28 Last updated: 2014-08-08Bibliographically approved

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Karlsson, Torbjörn

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